RO   EN PROJECT LEADER UNIVERSITY OF MEDICINE AND PHARMACY CLUJ-NAPOCA
AMPEROMETRIC IMMUNOSENSOR FOR OVARIAN AND UTERINE CANCER BIOMARKERS


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Objectives


The main objectives are:

1). Development of new immunosensing devices;
a. Electroactive surface design (fabrication of gold and carbon based screen-printed electrodes functionalized by thiolic compounds, carbon nanotubes, graphenes as nanobiolabels);
b. Bioelement design (choice of antibodies and/or aptamers);
c. Immunosensor development by different immobilization methods (biotin-avidin, selfassembling, conducting polymers);

2). Electroanalytical characterization of the new immunosensors (electrode surface characterization, electroanalytical performances);

3). Immunoelectrochemical method elaboration and prevalidation (design and optimization of the immunoreaction);

4). Real sample analysis and validation (selection of patients with ovarian cancer, endometriosis, uterine cancer in different stages of evolution, comparison with immunohistochemistry);